Interesting Fact

De' Medici. The hugely powerful Medici family from Italy were not only the power behind the throne, but also the throne itself for three periods of reign. Catherine De' Medici was the queen consort of Henry II of France (reigned 1547-59) and subsequently regent of France (1560-74), and was also one of the most influential personalities of the Catholic-Huguenot wars. Three of her sons were kings of France: Francis II, Charles IX, and Henry III. She was the daughter of Lorenzo the Magnificent, and niece of one Pope and sister of another. Catherine was actually probably the strongest figure in the entire period of French history, not only protecting her sons on the French throne, but fighting off and playing Catholic and Protestant forces against each other to lessen their influences on the French Kings.

 http://www.funtrivia.com/en/History/The-Reformation-19367.html